Tapentadol is partly metabolized through the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 so it innately has interactions with medications that enhance or repress the activity/expression of one or more of these enzymes, and also with substrates of those enzymes (on account of Opposition to the enzyme); some enzyme mediators/substrates have https://smedleyo366jdt9.wikicommunications.com/user