Pentobarbital will decrease the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of tinidazole by affecting hepatic/intestinal enzyme... https://socialicus.com/story5768865/5-semplici-tecniche-per-pentobarbital-icp