You will find there's launch of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors during the dorsal horn to reduce afferent soreness transmission and develop analgesia. Consequently, medicines like clonidine that target alpha-2 receptors can influence the transmission of pain. Combining these heart medication with clonidine https://derricky035lga5.wiki-jp.com/user