Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals from the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have recognized recurrent mutations in genes regulating tumor cell-microenvironment interac... https://williamk308bkt5.oneworldwiki.com/user