Injectable codeine is readily available for subcutaneous or intramuscular injection only; intravenous injection is contraindicated, as this can lead to nonimmune mast-cell degranulation and ensuing anaphylactoid reaction. Codeine suppositories are marketed in certain nations around the world. In Eire, new regulations arrived into effect on 1 August 2010[ninety] about codeine, https://codeingil.com/