Monoamine oxidase inhibitors are to blame for blocking the monoamine oxidase enzyme. The monoamine oxidase enzyme breaks down different types of neurotransmitters from the brain: norepinephrine, serotonin, dopamine, and tyramine. Still, it appears that evidently rasagiline is clinically efficient in adjunct to DA therapy for early/stable PD, but safinamide is ineffective https://johnp887cnx0.wikibriefing.com/user