Pentobarbital will decrease the level or effect of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Educador Closely. Strong or moderate CYP3A4 inducers significantly reduce guanfacine plasma concentrations and elimination half-life. pentobarbital will decrease the level or effect of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.... https://el-pentobarbital-es-un-ti73073.howeweb.com/30680030/la-guía-más-grande-para-qué-es-el-pentobarbital-sódico