At 3 days put up-MPTP, we discovered important microglial activation and up-regulation of CB2 cannabinoid receptors during the ventral midbrain. Procedure with Earn or even the CB2 receptor agonist JWH015 (four mg/kg, intraperitoneal) reduced MPTP-induced microglial activation, Whilst genetic ablation of CB2 receptors exacerbated MPTP systemic toxicity. Additionally, Long-term Earn https://win55.clinic/tin-tuc